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愛し野内科クリニック研究業績

著書
2011年3月「薬にも数値にも振り回されない高血圧最新療法」 (角川SSC新書 岡本卓 角川書店／角川グループパブリッシング)

2010年4月「糖尿病のみなさん、インスリンをやめてみませんか？」 (飛鳥新書)

2009年9月「インスリン注射も食事制限もいらない糖尿病最新療法」 (角川SSC新書78)

Takashi Okamoto, Lisa Okamoto, Michael P Lisanti, Masahiro Akishita
Switch to oral hypoglycemic agent therapy from insulin injection in patients with type 2 diabetes
Geriatics and Gerontology International　Volume 8 Issue 4  (p 218-226) (December 2008)

岡本卓、岡本里佐、秋下　雅弘、「インスリン離脱療法」、第50回日本老年医学会学術集会口頭発表（２００８年６月）

岡本卓、教育講演、生活習慣病にかかわる心の問題のとらえかた、人材育成ネットセミナー、２００８年８月および９月

岡本卓、水上勝義、清野 敏一、秋下　雅弘　「高齢者の服薬管理と指導」　Geriatric Medicine　2007年11月号（Vol.45　No.11）

岡本卓、パネルディスカッション、まちづくりシンポジウム、北見市総合計画策定のための、２００７年１１月

岡本卓、学術講演、遺伝子から生活習慣病にせまる、紋　別　医　師　会、２００６年１月

岡本卓: 招待講演"　ラフトとアルツハイマー病"　, 岡崎国立共同研究機構基礎生物学研究所, 岡崎, 3月(2001).
岡本卓: 招待講演"　アルツハイマー病とラフト"　, 国立精神　神経センター「神経研究所セミナー」, 小平, 2月(2001)

Analysis of the association of proteins with membranes.
Okamoto T, Schwab RB, Scherer PE, Lisanti MP.
Curr Protoc Cell Biol. 2001 May;Chapter 5:Unit 5.4.

Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.
Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K, Nishimoto I.
J Neurosci. 2001 Mar 15;21(6):1902-10.

Akt-mediated survival of oligodendrocytes induced by neuregulins.
Flores AI, Mallon BS, Matsui T, Ogawa W, Rosenzweig A, Okamoto T, Macklin WB.
J Neurosci. 2000 Oct 15;20(20):7622-30.

岡本卓　招待講演: "　カベオリンとアルツハイマー病"　, 東北大学, 仙台市, 1月(2000).

岡本卓:招待講演 "　カベオリンとアルツハイマー病"　, アルツハイマー学会, 東京, 2月(2000).

岡本卓:招待講演 "　カベオラとアルツハイマー病"　 , 神戸大学医学部, 神戸市, 6月 (2000).

Okamoto Takashi、招待講演: "　Possible signaling function of Presenilin-1"　, 第19回日本痴呆学会&COE国際ジョイントシンポジウム, 木更津, 9月(2000).

Okamoto Takashi: 招待講演"　Alzheimer's disease and rafts"　, 3rd Symposium and Annual Meeting of the Korean Society for Brain and Neural Science, Seoul, Korea, Dec. (2000).

岡本卓: 招待講演"　カベオリンとアルツハイマー病"　, 大阪大学蛋白質研究所セミナー「細胞膜マイクロドメインとシグナル伝達」,吹田市, 11月(2000).

岡本卓: 招待講演"　ラフトとアルツハイマー病"　, 東京医科歯科大学講演会, 東京, 11月(2000).

岡本卓: 招待講演"　ラフトとアルツハイマー病"　, 大塚製薬講演会, 徳島, 10月(2000).

岡本卓: "　カベオリンとアルツハイマー病"　, ラフトと信号伝達, 和光市, 7月(2000)

Okamoto Takashi: "　Alzheimer's disease"　, BSIリトリート2000, 大磯町, 9月(2000).

Caveolins, liquid-ordered domains, and signal transduction.
Smart EJ, Graf GA, McNiven MA, Sessa WC, Engelman JA, Scherer PE, Okamoto T, Lisanti MP.
Mol Cell Biol. 1999 Nov;19(11):7289-304. Review.

NMDA-receptors 1 and 2A/B coassembly increased in human epileptic focal cortical dysplasia.
Mikuni N, Babb TL, Ying Z, Najm I, Nishiyama K, Wylie C, Yacubova K, Okamoto T, Bingaman W.
Epilepsia. 1999 Dec;40(12):1683-7.

Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex.
Parolini I, Sargiacomo M, Galbiati F, Rizzo G, Grignani F, Engelman JA, Okamoto T, Ikezu T, Scherer PE, Mora R, Rodriguez-Boulan E, Peschle C, Lisanti MP.
J Biol Chem. 1999 Sep 3;274(36):25718-25.

Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.
Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T.
J Neurosci. 1999 Aug 1;19(15):6538-48.

Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.
Volonte D, Galbiati F, Li S, Nishiyama K, Okamoto T, Lisanti MP.
J Biol Chem. 1999 Apr 30;274(18):12702-9.

Decreased calmodulin-NR1 co-assembly as a mechanism for focal epilepsy in cortical dysplasia.
Mikuni N, Nishiyama K, Babb TL, Ying Z, Najm I, Okamoto T, Luders HO, Wylie C.
Neuroreport. 1999 May 14;10(7):1609-12.

岡本卓、招待講演: "　カベオリンとアルツハイマー病"　, 山之内製薬, つくば市, 9月(1999).
岡本卓、招待講演、東京大学、井原教授による招請、１９９９年２月８日
岡本卓、招待講演、RIKEN、貫名博士による招請、１９９９年２月１０日

岡本卓、座長、APP Biology in normal physiology and Alzheimer’s disease、
Organization of Symposium at annual meeting of American Society for Neurochemistry,
ニューオーリンズ、米国、１９９９年３月１４日から１７日

岡本卓、招待講演、Caveolae, DIG domains and organization of signaling molecules、
生理学研究所、伊佐教授による招請、１９９９年６月２８日

Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy.
Engelman JA, Zhang X, Galbiati F, Volonte D, Sotgia F, Pestell RG, Minetti C, Scherer PE, Okamoto T, Lisanti MP.
Am J Hum Genet. 1998 Dec;63(6):1578-87. Review. No abstract available.

Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types.
Ikezu T, Ueda H, Trapp BD, Nishiyama K, Sha JF, Volonte D, Galbiati F, Byrd AL, Bassell G, Serizawa H, Lane WS, Lisanti MP, Okamoto T.
Brain Res. 1998 Sep 7;804(2):177-92.

Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury.
Galbiati F, Volonte D, Gil O, Zanazzi G, Salzer JL, Sargiacomo M, Scherer PE, Engelman JA, Schlegel A, Parenti M, Okamoto T, Lisanti MP.
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10257-62.
岡本卓：セミナー招待講演、α-secretase mediated APP processing in caveolae
1998年6月8日、東京大学薬学部第４セミナー室（南館４階）

岡本卓、招待講演、Astra Inc、Jim Blossor博士による招待講演、
１９９８年１月１２日

岡本卓、招待講演、三菱化成ライフサイエンス研究所、永井博士による招請、
１９９８年６月９日

岡本卓、招待講演、癌研、尾形悦郎博士による招請、１９９８年６
月１０日

岡本卓、招待講演、山梨医科大学、大野教授による招請、１９９８
年９月２５日

岡本卓、招待講演、奈良先端技術研究所、貝淵教授による招請、
１９９８年１０月１日

岡本卓、招待講演、第３８回生物物理学会年次集会、Biomembrane、
１９９８年１０月３日

岡本卓、招待講演、名古屋大学、楠見教授による招請、
１９９８年１０月５日

岡本卓、招待講演、オハイオ州立大学、Lee Johnson教授による、
１９９８年１０月１２日

岡本卓、招待講演、ケースウエスタン大学病理研究所、Shu Chen教授による招請、
１９９８年１１月１６日

Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain.
Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP.
FEBS Lett. 1998 May 29;428(3):205-11.

Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein.
Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T.
J Biol Chem. 1998 Apr 24;273(17):10485-95.

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane.
Okamoto T, Schlegel A, Scherer PE, Lisanti MP.
J Biol Chem. 1998 Mar 6;273(10):5419-22. Review. No abstract available.

Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth.
Engelman JA, Wykoff CC, Yasuhara S, Song KS, Okamoto T, Lisanti MP.
J Biol Chem. 1997 Jun 27;272(26):16374

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins.
Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP.
J Biol Chem. 1997 Mar 7;272(10):6525-33.

Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes.
Tang Z, Okamoto T, Boontrakulpoontawee P, Katada T, Otsuka AJ, Lisanti MP.
J Biol Chem. 1997 Jan 24;272(4):2437-45.

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.
Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I.
EMBO J. 1997 Aug 15;16(16):4897-907.

Apoptosis in neurodegenerative diseases.
Nishimoto I, Okamoto T, Giambarella U, Iwatsubo T.
Adv Pharmacol. 1997;41:337-68. Review

岡本卓、招待講演、ケースウエスタン大学アルツハイマー病研究センター設立１０周年記念
アルツハイマー病の神経科学シンポジウム、１９９７年６月１９日〜２０日

Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.
Okamoto T, Takeda S, Giambarella U, Murayama Y, Matsui T, Katada T, Matsuura Y, Nishimoto I.
EMBO J. 1996 Aug 1;15(15):3769-77.

1回膜貫通構造受容体とG蛋白質
岡本卓，西本育夫*シュライナー病院ハーバード大学医学部麻酔科，
*心血管研究所マサチューセッツ総合病院ハーバード大学医学部内科実験医学, 14(2) : 183-187, 1996.

Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins.
Song KS, Scherer PE, Tang Z, Okamoto T, Li S, Chafel M, Chu C, Kohtz DS, Lisanti MP.
J Biol Chem. 1996 Jun 21;271(25):15160-5.

Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains.
Song KS, Li Shengwen, Okamoto T, Quilliam LA, Sargiacomo M, Lisanti MP.
J Biol Chem. 1996 Apr 19;271(16):9690-7.

Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle.
Tang Z, Scherer PE, Okamoto T, Song K, Chu C, Kohtz DS, Nishimoto I, Lodish HF, Lisanti MP.
J Biol Chem. 1996 Jan 26;271(4):2255-61.

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.
Scherer PE, Okamoto T, Chun M, Nishimoto I, Lodish HF, Lisanti MP.
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):131-5.
G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.
Yamatsuji T, Matsui T, Okamoto T, Komatsuzaki K, Takeda S, Fukumoto H, Iwatsubo T, Suzuki N, Asami-Odaka A, Ireland S, Kinane TB, Giambarella U, Nishimoto I.
Science. 1996 May 31;272(5266):1349-52.

Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP.
Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Martyn JA, Nishimoto I.
EMBO J. 1996 May 15;15(10):2468-75.

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.
Yamatsuji T, Okamoto T, Takeda S, Murayama Y, Tanaka N, Nishimoto I.
EMBO J. 1996 Feb 1;15(3):498-509.

岡本卓、招待講演、アルバートアインシュタイン大学、分子薬理学部門Charles S. Rubin博士による招請、
１９９６年７月２２日

岡本卓、招待講演、クリーブランドクリニック財団研究所、神経科学部門Bruce D. Trapp博士による招請、
１９９６年８月２７日

岡本卓、招待講演、テキサスA&M大学、医学薬理・毒物学部門、James L. Way博士による招請、
１９９６年９月９日

岡本卓、招待講演、マサチューセッツ工科大学、Martin L. Yarmush博士による招請、
１９９６年９月１２日

岡本卓、招待講演、テネシー大学、薬理学部門、Patel教授による招請、
１９９６年９月１７日

岡本卓、招待講演、バンダービルト大学、分子神経科学センター、Randy D.Blakely教授による招請、
１９９６年９月１８日

岡本卓、招待講演、カンザス大学医学部生化学部門、Billy G Hudson教授による招請、
１９９６年１０月３日

岡本卓、招待講演、フロリダ大学薬理学教室、Ed C Meyer博士による招請、
１９９６年１０月１０日

岡本卓、招待講演、カリフォルニア大学アーバイン校、生化学部門、Stuart M. Arfin教授による招請、
１９９６年１０月１６日

岡本卓、招待講演、ケースウエスタン大学、Bruce D Trapp博士による招請、
１９９６年１０月２１日

岡本卓、招待講演、アルバートアインシュタイン大学、Michael Prystowsky博士による招請、
１９９６年１１月４日

岡本卓、招待講演、バンダービルト大学、分子神経科学センターRandy D.Blakely教授による招請、
１９９６年１１月１１日

Evidence for a regulated interaction between heterotrimeric G proteins and caveolin.
Li S, Okamoto T, Chun M, Sargiacomo M, Casanova JE, Hansen SH, Nishimoto I, Lisanti MP.
J Biol Chem. 1995 Jun 30;270(26):15693-701.

In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor.
Ikezu T, Okamoto T, Giambarella U, Yokota T, Nishimoto I.
J Biol Chem. 1995 Dec 8;270(49):29224-8.
Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.
Lang J, Nishimoto I, Okamoto T, Regazzi R, Kiraly C, Weller U, Wollheim CB.
EMBO J. 1995 Aug 1;14(15):3635-44. Erratum in: EMBO J 1995 Sep 15;14(18):4639.

Ligand-dependent G protein coupling function of amyloid transmembrane precursor.
Okamoto T, Takeda S, Murayama Y, Ogata E, Nishimoto I.
J Biol Chem. 1995 Mar 3;270(9):4205-8.

岡本卓、招待講演、ハーバード大学、MGH、外科部門、Martin L. Yarmush博士による招請、
１９９５年１２月

Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.
Ikezu T, Okamoto T, Murayama Y, Okamoto T, Homma Y, Ogata E, Nishimoto I.
J Biol Chem. 1994 Dec 16;269(50):31955-61.
An intrinsic guanine nucleotide exchange inhibitor in Gi2 alpha. Significance of G-protein self-suppression which antagonizes receptor signal.
Okamoto T, Murayama Y, Strittmatter SM, Katada T, Asano S, Ogata E, Nishimoto I.
J Biol Chem. 1994 May 13;269(19):13756-9.

岡本卓、招待講演、第１４回Biennial Meeting of the International Society for Neurochemistry、フランス、
１９９３年８月

Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor.
Takahashi K, Murayama Y, Okamoto T, Yokota T, Ikezu T, Takahashi S, Giambarella U, Ogata E, Nishimoto I.
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11772-6.

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)
Nishimoto I, Okamoto T, Matsuura Y, Takahashi S, Okamoto T, Murayama Y, Ogata E.
Nature. 1993 Mar 4;362(6415):75-9.

Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif.
Ikezu T, Okamoto T, Ogata E, Nishimoto I.
FEBS Lett. 1992 Oct 12;311(1):29-32.

Measurement of GTP gamma S binding to specific G proteins in membranes using G-protein antibodies.
Okamoto T, Ikezu T, Murayama Y, Ogata E, Nishimoto I.
FEBS Lett. 1992 Jun 29;305(2):125-8.

IGF-II受容体とG蛋自認識配列
西本育夫,岡本卓
東京大学医学部第四内科学教室
医学のあゆみ, 161(1) : 43-49, 1992.

Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and alpha 2-adrenergic receptors based upon characteristics in primary structure.
Okamoto T, Nishimoto I.
J Biol Chem. 1992 Apr 25;267(12):8342-6.

Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation.
Okamoto T, Murayama Y, Hayashi Y, Inagaki M, Ogata E, Nishimoto I.
Cell. 1991 Nov 15;67(4):723-30.
Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide.
Okamoto T, Nishimoto I.
Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8020-3.

Distinct mode of G protein activation due to single residue substitution of active IGF-II receptor peptide Arg2410-Lys2423: evidence for stimulation acceptor region other than C-terminus of Gi alpha.
Okamoto T, Ohkuni Y, Ogata E, Nishimoto I.
Biochem Biophys Res Commun. 1991 Aug 30;179(1):10-6.

Guanine nucleotide-binding protein interacting but unstimulating sequence located in insulin-like growth factor II receptor. Its autoinhibitory characteristics and structural determinants.
Nishimoto I, Ogata E, Okamoto T.
J Biol Chem. 1991 Jul 5;266(19):12747-51.

Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21.
Okamoto T, Asano T, Harada S, Ogata E, Nishimoto I.
J Biol Chem. 1991 Jan 15;266(2):1085-91.

Calcium as an intracellular signal for cell proliferation response. Studies on IGF-II induced DNA synthesis in Balb/c 3T3 mouse fibroblasts.
Ogata E, Nishimoto I, Matsunaga H, Murayama Y, Okamoto T, Kojima I.
Contrib Nephrol. 1991;91:2-6. Review.
Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate.
Murayama Y, Okamoto T, Ogata E, Asano T, Iiri T, Katada T, Ui M, Grubb JH, Sly WS, Nishimoto I.
J Biol Chem. 1990 Oct 15;265(29):17456-62.

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor.
Okamoto T, Katada T, Murayama Y, Ui M, Ogata E, Nishimoto I.
Cell. 1990 Aug 24;62(4):709-17.

Insulin-like growth factor-II/mannose 6-phosphate receptor is incapable of activating GTP-binding proteins in response to mannose 6-phosphate, but capable in response to insulin-like growth factor-II.
Okamoto T, Nishimoto I, Murayama Y, Ohkuni Y, Ogata E.
Biochem Biophys Res Commun. 1990 May 16;168(3):1201-10.

Familial disorder with increased number of insulin receptors: a new category of insulin receptor abnormality.
Okamoto T, Kadowaki T, Takaku F, Suzuki K, Shiba T, Mashiko S, Kanazawa Y, Akanuma Y, Kasuga M.
J Clin Endocrinol Metab. 1986 Oct;63(4):865-71.
門脇　孝、岡本　卓、柴　輝男、泉　哲郎、春日　雅人 (1986).
家族性インスリン受容体増多症とその周辺．　糖尿病学（診断と治療社、東京）　77-106.